ANTIO and SESAMIO are dietary supplement products developed from plant-derived materials and natural honey. ANTIO is formulated from four fresh medicinal plants—kariyat (Andrographis paniculata), elephant garlic (Allium ampeloprasum), butterfly pea (Clitoria ternatea), and turmeric (Curcuma longa)—using an innovative extraction process based on osmotic dehydration, in which natural honey serves as the osmotic agent. SESAMIO is a dietary supplement produced from black sesame seeds (Sesamum indicum) and natural honey using the same innovative extraction technique. Both products were evaluated for their biological and pharmacological activities and further assessed through clinical investigations involving conditions such as diabetic foot ulcers, deep vein thrombosis, and thrombosis (blood clot formation). The innovation underlying ANTIO and SESAMIO lies in the utilization of fresh herbal materials and fresh black sesame seeds, combined with a non-chemical extraction process that preserves natural physicochemical properties and essential nutrients. The production process avoids the use of artificial preservatives, synthetic additives, or chemical extraction agents.