There were 8 projects in the Economic Animal Production for Food Security and Safety Research including 1) Genetic parameter estimation and molecular marker for genetic improvement in Nile tilapia from biofloc system to organic aquaculture by selection 2) Effect of garlic extract on sex reversal of production Nile Tilapia 3) Efficacy of Garlic Extract Added Feed in Nile Tilapia Culture 4) Potential of Thai herbs and probiotics on growth and nonspecific immune response in organic Tilapia culture system 5) Development of synbiotics bioproducts affecting on growth performance, disease resistance, digestive enzyme activity and im?munological response in fry Nile tilapia 6) Production and Health Management of Tilapia for Prosperous and Sustainable Business 7) Egg quality improvement by using Spirulina platensis 8) Suitable use of fermented fish by-product and snail in diets for fish in aquaponics system to organic aquaculture. The first-year results were as follows; The genetic improvement in Nile tilapia from biofloc system to organic aquaculture by selection showed an increase of both body weight (BW) and total length (TL). The correlations between BW and TL (Phenotypic correlation; 0.92, Genotypic correlation; 0.996) were high. Genetic correlations for BW and TL between different feeds (Organic certified pellets and duck weed) was 0.99 implying that no significance in genotype by environmental interaction. The 50 percent garlic extract additive feed tended to provide the best growth performances in tilapia fingerlings. The 17?-MT provided the best sex reversal rate (99.00?0.89 % Male), while the Nile tilapia larvae fed with 50 percent garlic extracts were quite similar (89.50?1.00 % Male). Tilapia received 0.5%(w/w) garlic extract additive feed for 16 weeks were significantly increased in production (p<0.05). Phyllanthus emblica extract can supplement in diet replaced vitamin C and diets supplemented with Saccharomyces cerevisiae 0.2% (YS) and Lactobacillus acidophilus 0.2% + Saccharomyces cerevisiae 0.2% (LY) without adverse effects on growth parameters, non-specific immune response and carcass compositions of tilapia. In addition, two isolates of probiotic bacteria, CR4-1 and CR10-5, in the digestive system of fry Nile tilapia from four Nile tilapia farms in Chiang Mai and Chiang Rai provinces were selected to promote growth and inhibit pathogens. These will be used to produce a synbiotics combined with coffee silver skin (agricultural wastes) which was used as prebiotic and growth and immune stimulant in Tilapia larvae. Three major fish bacterial pathogens include Flavobacterium columnare, Streptococcus agalactiae, and Aeromonas hydrophila. Fish death usually occurs during season change from late summer to rainy season; March – July. In cases of fish stress, Trichodina may become pathogenic ectoparasite interferingwith feeding and respiration of small fish. The massive deaths of cage cultured tilapia due to the abrupt changes in weather and water quality were reported every year. Tilapia farmers' associations have been formally and informally set up in order to get the benefit from seed and commercial feed buying as well as product selling. There are still a room for Good Aquaculture Practices (GAP) including hatchery, nursery, and on-farm culture because most farmers lack of the motivation to improve their farms due to the GAP fish product is not high. The eggs from the laying hen fed 0.15% Spirulina platensis can develop to be functional food for the specific need of the consumer. The fermented fish by-product and snail can 50% partially replace dietary protein from fishmeal in Snake head fish culture.