This research is concerned on the study of Management for Marketing Promotion to Commercialization of Maejo University : A Study of Hom Chuen Mask Spray. The research aims to study the opinions of consumers after using Hom Chuen Mask Spray for a month, including study on consumer behavior in purchasing anti-Covid-19 products and create marketing promotion management guidelines by using mixed methods research. This research found that the satisfaction of 20 people after using the mask spray overall was at the highest level are the product has a fresh scent that makes breathing easier and ensuring the benefits of preventing pathogens in the present situation. In addition, it was found that the purchase behavior of anti-Covid-19 products at a high level (x?= 4.19, S.D. = 0.92) was interested in buying a spray mask to prevent small germs and PM 2 .5 dust. According to interviews with 3 academic experts in marketing promotion and management, it was found that Maejo University should focus on effective management principles which are planning, organizing, leading and controlling for advertising, personal selling, sales promotion and public relations.