Currently, Thai population and the world population have entered the aging society. The important problem is how to maintain elderly people in good health and protected from diseases. Diseases found in the elderly are diabetes, cancer, cardiovascular disease caused by blockage of fat, hypertension, and many others. One way to solve this problem is to eat healthy and safe food without chemical contamination. Highly nutritious rice beneficial to the body contains antioxidants, anthocyanins, gamma, orizanol, and vitamins. These nutrients help to slow down the degeneration of cells, reduce the risk of cancer and reduce blood sugar. Most nutritious rice is pigmented rice i.e black and red. In addition, Thai rice production uses harmful chemicals, which is another problem that directly affects producers, consumers and the environment. From the problems found, the research team recognized this importance. Therefore, there is a demand for breeding of rice with high nutrient content, resistant to disease and insects for organicproduction to make it suitable for elderly people and healthy diet, as well as reducing the use of chemicals to be safe for manufacturers and consumers and being environmentally friendly. The study includes the following: Sub-project 1 Yield trials, plant protection and seed production of non-photoperiod sensitive, semi-dwarf, aromatic, red, non-glutinous/glutinous and high nutritional value of Sang Yod Phatthalung rice lines. Solve the problem of cancer and heart disease Sub-project 2 Selection, observation and yield trials of non-photoperiod sensitive, semi dwarf, aromatic non-glutinous, resistant to diseases and insect and high nutritional value of Hom Mali Dang rice lines. Solve cancer problems, heart disease and reduce the use of chemicals. Sub-project 3 Study of chemical and milling quality of rice varieties from Subproject 1 and Subproject 2. Sub-project 4 Improvement of rice varieties to increase anthocyanins by molecular marker-assisted selection for increased nutritional values. Solve cancer problems. Sub-project 5 Improvement of rice varieties to increase lutein or zeaxanthin by gene specific DNA marker selection. Solve the problem of macular degeneration. Subproject 6 Improvement of rice variety to increase resistant starch using molecular marker-assisted selection. Solve diabetes problems.