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From the results of the study on the growth, inflorescence, fruiting, yield and product quality of 18 lines of F1-hybrid longan in comparison with E-Daw variety, it was shown that growth in terms of canopy width, plant height and stem diameter did not show any difference. Only 6 lines of F1-hybrid longan that were F1-4 (E-Daw 27-1 x SiChompoo 12), F1-3 (E-Daw 27-1 x SiChompoo12), F1-1 (E-Daw 27-1 x SiChompoo 12), F1-4 (SriChompoo7x DawKanKheng 8), F1-5 (DawKanKheng 7 x SiChompoo 12) and F1-1 (KrobKahti x E-Daw), were found to flower. The shortest time to flower from seed germination was 3 years and 11 months, whereas the other hybrids took more than 4 years. After flowering, only one line of the hybrid, F1-4 (E-Dow 27-1 x SiChompoo 12), could set the fruits. The characteristics of the hybrids showed smooth rind, color of aril was creamy white. The texture of flesh was crispy and sweet and it had a big seed. The physical characteristics of F1-hyrid as follow: fruit, aril and seed weight was 11.53 g, 7.25 g, and 2.25 g, respectively. Fruit width and length was 25.63 mm and 27.45 mm, respectively and total soluble solids was 18.11obrix.